October 29, 2026

Levothyroxine: Why Your Thyroid Pill Might Not Be Working w/ Dr Angela Mazza

Levothyroxine: Why Your Thyroid Pill Might Not Be Working w/ Dr Angela Mazza

If your thyroid pill is working, why do you still feel tired and foggy?

Many women come through our pharmacy with that issue. One thyroid pill turned into 5 prescriptions, and they don’t feel any better. 

No one went back to ask one question: Is the thyroid pill actually working?

My guest this week isn’t afraid to ask. Dr. Angela Mazza is a triple board-certified endocrinologist, and one of the few in her field willing to look at thyroid therapy with a different lens.


 

What You'll Discover In This Episode

  • Why some levothyroxine patients end up on statins, blood pressure pills & antidepressants

  • The most common thyroid-pill mistake (a simple nightstand fix)

  • The hidden DNA quirk blocking T3 conversion in 10-15% of patients

  • Why oral estrogen can change your thyroid dose,..but topicals don’t

  • How everyday medications & gut conditions knock thyroid levels off

  • The one thyroid symptom women tend to ignore

  • Why fast weight loss on GLP-1s can make your thyroid numbers worse

  • How menopause & coming off birth control alter your thyroid dosage

  • Why Dr Angela believes levothyroxine isn’t the right answer for everyone


About the Guest

Dr. Angela Mazza, DO, ABAARM, FAAMFM, ECNU, CDE, is a board-certified endocrinologist and founder of the Metabolic Center for Wellness in Oviedo, Florida. With more than two decades of clinical and academic experience, she is nationally recognized for her integrative and functional approach to endocrine disorders, particularly thyroid health, adrenal dysfunction, and metabolic disease. 

She holds fellowships in Anti-Aging and Functional Metabolic Medicine, is certified in Endocrine Neck Ultrasound and Diabetes Education, and has published research on autoimmune thyroiditis and hormone balance. A frequent speaker at A4M, IFM, and Endocrine Society conferences, she hosts the podcast "Thyroid Talk with Dr. Angela Mazza," serves on the faculty of the Metabolic Medical Institute and the Orlando College of Osteopathic Medicine, and was named Greater Orlando's Top Physician in Endocrinology.

To learn more, visit drangelamazza.com and check out her YouTube channel: @drangelamazza.

 

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